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KMID : 0604520090350020079
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Journal of the Society of Cosmetic Scientists of Korea
2009 Volume.35 No. 2 p.79 ~ p.89
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The Effects of Ethanol on Nano-emulsions Containing Quercetin Prepared by Emulsion Inversion Point Method
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Park Soo-Nam
Won Bo-Ryoung
Kang Myung-Kyu
Ahn You-Jin
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Abstract
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The objective of this study was to find out the stable formulation of nano-emulsion containing high concentration of quercetin and to investigate the effect of an ethanol on the nano-emulsion prepared by POE (30) hydrogenated castor oil (HCO-30)/oil/quercetin/ethanol/water system. Nano-emulsion was prepared using emulsion inversion point (EIP) method as low-energy method plus homogenizer as high-energy method. To evaluate effect of ethanol and other components on the nano-emulsion, physical properties such as droplet size, morphology, and size distribution were determined. The optimal quercetin concentration was 0.2 % on the nano-emulsion. The droplet diameter was below 300 nm at the HCO-30 concentration below 2.00 %. Nano-emmulsion containing 4.75 % HCO-30 was the most stable and its mean droplet size was 172.40 nm. Finally, the size of nano-emulsion containing 4.00 % ethanol was 128.15 nm and size distribution was also narrow. The results showed that the breakdown process of this nano-emulsion could be attributed to Ostwald ripening. This study about effect of ethanol on the nano-emulsion showed that loading capacity of drug could be increased by using a small amount of ethanol. As prepared stable nano-emulsion, this study showed that these results could be applied to pharmaceutics, cosmetic including skin-care products, perfume and etc.
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KEYWORD
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nano-emulsion, emulsion inversion point, quercetin, size distribution, Ostwald ripening
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